The centrosome is crucial for neuronal migration and polarisation, processes that are disrupted in a number of neurodevelopmental disorders including schizophrenia. Mutation of DISC1, associated with increased risk of schizophrenia and psychiatric illness, has been shown to affect the centrosome, but the mechanisms involved have not been elucidated. In this issue of EMBO Reports, Fukuda and colleagues demonstrate that a DISC1‐interacting protein, CAMDI, suppresses the activity of the histone deacetylase HDAC6, thereby promoting centrosome stability and consequently neuronal migration . Loss of CAMDI leads to cortical migration defects and behavioural phenotypes that model autism spectrum disorders and which can be rescued by inhibition of HDAC6. The study provides novel mechanistic insight into centrosome regulation in neurodevelopment.
See also: T Fukuda et al (December 2016)
The centrosome is the main microtubule organising centre in the cell and hence important for cytoskeleton function. Studies of centrosomal protein mutations have revealed roles of the centrosome in correct neuronal migration and cell polarisation, key steps in the patterning of the developing nervous system. Noteworthy, mutations in proteins located at the centrosome have been identified in patients with psychiatric disorders.
The disrupted‐in‐schizophrenia 1 (DISC1) gene has been identified as a strong risk factor for schizophrenia and psychiatric disorders. DISC1 is localised throughout the cell, including at the centrosome, primary cilia, microtubules, mitochondria and nucleus. Previous studies have demonstrated that …